Oct 15, - WebMD takes a look at the side effects of popular sleeping pills. They are usually not recommended for long-term treatment of sleeping problems. the brain as do benzodiazepines, include Lunesta, Sonata, and Ambien. 5 days ago - Zolpidem (Ambien) for insomnia is generally safe in the short term, Ambien and similar sleep medications can be effective, and they're But there can be concerning side effects. Sleep medications can be useful in the short term, but relying on them usually isn't the best long-term solution for insomnia. This is true if you take it for a short period, or even if you take it for a long time. The brief nature of these side effects suggests the drug does not do permanent.