Jul 23, - 1 Answer - Posted in: ambien, lunesta, bipolar disorder, insomnia - Answer: yes, there is a big difference. Ambien is shorter acting if its not the. Mar 31, - If those don't do the trick and your insomnia isn't caused by an underlying condition, there are medications that can help. Lunesta and Ambien ?How they work · ?Dosage · ?Side effects · ?Interactions. Jun 6, - Moreover, Ambien and Lunesta don't require a strict medication schedule; the patient needs only to dedicate a full 8 hours to sleep and let the.
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